Separation Technique of Enantiomers
نویسندگان
چکیده
منابع مشابه
Chromatographic Separation of Vitamin E Enantiomers.
Vitamin E is recognized as an essential vitamin since its discovery in 1922. Most vegetable oils contain a mixture of tocopherols and tocotrienols in the vitamin E composition. Structurally, tocopherols and tocotrienols share a similar chromanol ring and a side chain at the C-2 position. Owing to the three chiral centers in tocopherols, they can appear as eight different stereoisomers. Plant so...
متن کاملSeparation of enantiomers and conformers of Tofi sopamon
Due to different physiological activities, the chromatographic separation of enantiomers is an important task in drug discovery and development. The determination of the enantiomeric excess (ee) is often done with supercritical fl uid chromatography (SFC) in combination with chiral stationary phases. Since fi nding the right stationary phase that provides separation of the enantiomers is diffi ...
متن کاملCapillary zone electrophoresis separation of enantiomers of lisuride.
Lisuride is an ergot alkaloid derivative with dopaminergic activity. It is used for treatment of Parkinsonism and some other diseases associated with high level of prolactine. Lisuride is a chiral compound derived from natural ergot alkaloids. A new capillary zone electrophoresis (CZE) method capable of separating the enantiomers of lisuride was developed. Using the optimized conditions (acidic...
متن کاملChiral separation of indapamide enantiomers by capillary electrophoresis.
PURPOSE Indapamide is probably the most frequently prescribed diuretic drug, generally being used for the treatment of hypertension. It contains a chiral center in its molecule; is marketed as a racemic mixture; but there are rather few studies regarding the pharmacokinetic and the pharmacological effect differences of the two enantiomers. Our aim was the development of a simple, rapid and prec...
متن کاملSeparation of Pharmaceutical Enantiomers using Supercritical Fluid Technology
The use of supercritical fluids as chromatographic mobile phases provides rapid separations with high efficiency, favoring their use in enantioselective separations. Supercritical fluid technology (SFC) is a versatile tool in the purification, enantioseparation and large-scale production of enantiomers of pharmaceuticals over comparable liquid chromatographic methods and is gaining popularity i...
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ژورنال
عنوان ژورنال: Analytical Sciences
سال: 2020
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.highlights2011